英文名稱： 2-Toluene sulfonamide
【Product Name】2-Methylbenzene-1-sulfonamide 鄰甲苯磺酰胺
【RTECS Class】Tumorigen; Mutagen; Reproductive Effector; Primary Irritant
Physical and Chemical Properties
【Appearance】Octahedral crystals from alc, prisms from water.
【Solubility in water】Slightly soluble
【Melting Point】155 - 156
【Vapor Pressure】0.00017 (25 C)
【Heat Of Vaporization】57.3 kJ/mol
【Usage】Starting material for preparation of saccharin. Ortho- & para-toluenesulfonamide mixt is used as a reactive plasticizer.
First Aid Measures
【Ingestion】The possible benefit of early removal of some ingested material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation. Activated charcoal activated charcoal binds most toxic agents and can decrease their systemic absorption if administered soon after ingestion. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.
【Inhalation】Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
【Skin】Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
【Eyes】Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.
Handling and Storage
【Storage】Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
【Handling】All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
【Skin】Various dermatological reactions, including rash, pruritus, erythema nodosum, and quite severe and often fatal erythema multiforme of the stevens-johnson type have been reported. This serious reaction has been reported even with the use of ophthalmic preparations. Rashes and fever appear ten days after initiation of therapy and reoccur immediately upon additional courses of the therapy.
【Ingestion】Nausea and vomiting are likely to occur.
【EC Risk Phrase】R 40 36/37/38
【EC Safety Phrase】S 26 36/37/39
Exposure Controls/Personal Protection
【Personal Protection】Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
【Respirators】Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
【Exposure Effects】headache, depression, and hallucinations have been reported with therapeutic use of sulfonamides. Coma and seizures were reported following a large overdose of sulfasalazine in one patient. Tremor occurred in one patient following a fixed-dose combination of trimethoprim/sulfamethoxazole.
Fire Fighting Measures
【Fire Fighting】Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
Accidental Release Measures
【Small spills/leaks】Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability and Reactivity
【Incompatibilities】Strong oxidizing agents.